Lumbrokinase is a complex of enzymesEnzymes are proteins that accelerate chemical reactions in the body. They ensure the occurrence of metabolic processes such as food digestion, energy release, cell formation, and many others. isolated from earthworms (most commonly the species Lumbricus rubellus). These enzymes have powerful fibrinolytic properties, that is, they are able to dissolve blood clots and improve blood circulation. Lumbrokinase is used in medicine and as a dietary supplement for the prevention and treatment of cardiovascular diseases, as well as to improve overall health.
Opening history
Lumbrokinase was discovered in traditional Chinese medicine research, where earthworms were used to treat circulatory diseases. In the 1980s, scientists isolated active enzymes from worms that were effective in dissolving fibrinFibrin is an insoluble protein substance formed during blood clotting and precipitating as a tangle of threads., a protein that forms blood clots.
Mechanism of action
Lumbrokinase acts as a fibrinolytic agent, breaking down fibrin and preventing the formation of blood clots. Here are the main mechanisms of its action:
- Direct breakdown of fibrin:
- Lumbrokinase directly destroys fibrin, dissolving already formed blood clots.
- Plasminogen activation:
- The enzyme helps convert plasminogen into plasmin — a natural enzyme in the body that breaks down fibrin.
- Inhibition of platelet aggregation:
- Lumbrokinase reduces platelet bonding, which prevents the formation of new blood clots.
- Improving microcirculation:
- The enzyme helps to improve blood flow in small vessels, which is especially important for the prevention of ischemia.
Useful properties of lumbrokinase
- Prevention and treatment of thrombosis:
- Lumbrokinase helps prevent the formation of blood clots and dissolves existing ones, reducing the risk of stroke, heart attack and other cardiovascular diseases.
- Improved blood circulation:
- The enzyme helps improve blood microcirculation, which is useful for people with varicose veins, atherosclerosis and hypertension.
- Lowering blood pressure:
- Lumbrokinase helps relax the walls of blood vessels and improves blood flow, which helps reduce blood pressure.
- Antioxidant effect:
- The enzyme helps reduce oxidative stress by protecting cells from free radical damage.
- Anti-inflammatory effect:
- Lumbrokinase can reduce the level of inflammation in the body, which is useful in chronic diseases.
- Support for brain health:
- Improving blood circulation can reduce the risk of cognitive impairments such as dementia and Alzheimer’s disease.
Application of lumbrokinase
Lumbrokinase is used in the form of dietary supplements, which are available in the form of capsules or tablets. The usual dosage is 20-40 mg per day, but the exact dose depends on the manufacturer’s recommendations and health condition.
Indications for use
- Prevention and treatment of thrombosis.
- Atherosclerosis and peripheral artery diseases.
- Hypertension.
- Varicose veins.
- Rehabilitation after a stroke or heart attack.
- Improvement of the general condition of the cardiovascular system.
Contraindications and side effects
Lumbrokinase is generally well tolerated, but there are some limitations:
- Contraindications:
- Hemophilia and other blood clotting disorders.
- Taking anticoagulants (warfarin, heparin, etc.).
- Upcoming surgical operations (due to the risk of bleeding).
- Pregnancy and lactation (requires a doctor’s consultation).
- Side effects (rare):
- Bleeding (nasal, gingival).
- Allergic reactions (if there is sensitivity to the components).
How to take lumbrokinase
- The supplement is taken on an empty stomach, usually in the morning or evening, to enhance its effectiveness.
- It is not recommended to combine with alcohol or anticoagulants without consulting a doctor.
Comparison with nattokinase
Lumbrokinase is considered a more potent fibrinolytic than nattokinasedue to its ability to directly break down fibrin and activate plasminogen. However, it is less well understood and can cause more side effects.
Conclusion
Lumbrokinase is a powerful enzyme with proven fibrinolytic properties that helps maintain a healthy cardiovascular system. It is effective for the prevention and treatment of thrombosis, improving blood circulation and lowering blood pressure.