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Nattokinase-treatment of thrombosis, Application, Useful properties

Nattokinase is an enzyme that is produced by the bacterium Bacillus subtilis ( natto strain) during the fermentation of soybeans in the preparation of the traditional Japanese dish natto. Nattokinase is known for its powerful fibrinolytic properties, that is, the ability to dissolve blood clots and improve blood circulation. It is widely used as a dietary supplement to support the health of the cardiovascular system.

Opening history

Nattokinase was discovered in the 1980s by Japanese researcher Hiroyuki Sumi. , who studied the enzymatic properties of natto and found that this enzyme has a strong ability to dissolve fibrin, a protein involved in blood clot formation.

Mechanism of action

Nattokinase acts as a fibrinolytic enzyme, meaning it is able to break down fibrin, which is the main component of blood clots. Here’s how it works:

  1. Direct action on fibrin:
    • Nattokinase directly breaks down fibrin, dissolving already formed blood clots.
  2. Plasminogen activation:
    • Nattokinase stimulates the conversion of plasminogen to plasmin — the body’s natural enzyme that breaks down fibrin.
  3. PAI-1 inhibition:
    • Nattokinase reduces the level of plasminogen activator inhibitor-1 (PAI-1), which contributes to increased fibrinolytic activity.

Useful properties of nattokinase

  1. Prevention and treatment of thrombosis:
    • Nattokinase helps prevent the formation of blood clots and dissolves existing ones, reducing the risk of stroke, heart attack and other cardiovascular diseases.
  2. Improved blood circulation:
    • The enzyme helps improve blood microcirculation, which is especially useful for people with varicose veins, atherosclerosis and hypertension.
  3. Lowering blood pressure:
    • Nattokinase helps relax the walls of blood vessels and improves blood flow, which helps reduce blood pressure.
  4. Antioxidant effect:
    • The enzyme helps reduce oxidative stress by protecting cells from free radical damage.
  5. Support for brain health:
    • Improving blood circulation can reduce the risk of cognitive impairments such as dementia and Alzheimer’s disease.
  6. Anti-inflammatory effect:
    • Nattokinase can reduce the level of inflammation in the body, which is useful in chronic diseases.

Application of nattokinase

Nattokinase is used in the form of dietary supplements, which are available in the form of capsules or tablets. The usual dosage is 1000-2000 FU (fibrinolytic units) per day, but the exact dose depends on the manufacturer’s recommendations and health condition.

Indications for use

  • Prevention and treatment of thrombosis.
  • Atherosclerosis and peripheral artery diseases.
  • Hypertension.
  • Varicose veins.
  • Rehabilitation after a stroke or heart attack.
  • Improvement of the general condition of the cardiovascular system.

Contraindications and side effects

Nattokinase is generally well tolerated, but there are some limitations:

  1. Contraindications:
    • Hemophilia and other blood clotting disorders.
    • Taking anticoagulants (warfarin, heparin, etc.).
    • Upcoming surgical operations (due to the risk of bleeding).
    • Pregnancy and lactation (requires a doctor’s consultation).
  2. Side effects (rare):
    • Bleeding (nasal, gingival).
    • Allergic reactions (if there is sensitivity to soy or natto).

How to take nattokinase

  • The supplement is taken on an empty stomach, usually in the morning or evening, to enhance its effectiveness.
  • It is not recommended to combine with alcohol or anticoagulants without consulting a doctor.

Nattokinase in food

Nattokinase is found in the traditional Japanese dish natto, which is made by fermenting soybeans with the bacterium Bacillus subtilis. . However, natto has a specific taste and smell that not everyone likes, so supplements with nattokinase have become a popular alternative.

Conclusion

Nattokinase is a powerful enzyme with proven fibrinolytic properties that helps maintain a healthy cardiovascular system. It is effective for the prevention and treatment of thrombosis, improving blood circulation and lowering blood pressure. However, it is recommended that you consult your doctor before starting treatment, especially if you have a chronic medical condition or are taking medication.