Thesamorelin is a synthetic analog of the hormone GHRH.

Tesamorelin — a detailed review of the peptideA peptide is a molecule consisting of a chain of amino acids linked together by peptide bonds. Peptides are shorter chains than proteins and usually contain from 2 to 50 amino acids. When the number of amino acids in a chain exceeds 50, such molecules are called proteins. Peptides can perform various functions in the body, including: Hormones, Neuropeptides, Antibiotics, Antioxidants

Tesamorelin is a synthetic ghrelin-releasing hormone (GHRH) analogapproved by the FDA for the treatment of lipodystrophy in HIV-infected patients. , but it is also being investigated in the context of anti-aging therapy, fat burning and recovery.

1. Mechanism of action

Tesamorelin acts through the hypothalamic-pituitary axis:

Binds to GHRH receptors in the pituitary gland.
Stimulates the release of growth hormone (GH).
GH enhances the synthesis of IGF-1 in the liver, which leads to:
- – Acceleration of lipolysis (breakdown of fat, especially visceral).
- 🏋️ Improve muscle tone.
- Нейро Neuroprotection and cognitive support.

Difference from other GHRPs (for example, GHRP-2/6):

Thesamorelin does not directly affect ghrelin receptors, so it does not cause severe hunger.
It gives a more physiological release of GH (closer to the natural pulsation).

2. Main effects

① Visceral fat reduction (main application)

Reduces the volume of abdominal fat by 15-20% in 3-6 months (studies in HIV patients).
It does not affect subcutaneous fat as much as visceral fat.

, Anti-age effects

Improves skin condition (increases collagenCollagen is a fibrillar protein, one of the main building elements of the body. It constitutes a significant part of connective tissues such as skin, tendons, joints, bones, and cartilage. Collagen provides strength, elasticity, and structural integrity to these tissues, giving them the ability to resist stretching. synthesis).
Supports bone density.
May slow down sarcopenia (muscle loss with age).

, Cognitive benefits

Potentially protects against neurodegeneration (Alzheimer’s disease).
Improves sleep quality (by normalizing GH secretion).

④ Sports application

Minor anabolic effect (less pronounced than that of IPA/The GRF mod).
Faster recovery from injuries.

3. Application Protocols

🔹 Medical dosages (for lipodystrophy)

2 mg subcutaneously once a day (standard regimen).
Course: 6-12 months.

🔹 For fat burning/anti-aging therapy

1-2 mg / day (in the evening or in the morning on an empty stomach).
Optimal course: 3-6 months.

Комбинации Combinations with other peptides

+ CJC-1295 (without DAC) – increased GH emission.
+ Ipamorelin -synergy without prolactin growth.

4. Side effects

Hyperglycemia (GH reduces insulin sensitivity).
Edema/tunnel syndrome (fluid retention).
Headaches (rare).
Activation of latent tumors (contraindicated in oncology).

Important: Monitor blood sugar and IGF-1 levels during the course.

5.Tezamorelin vs. Other peptides

The peptide	Main action	Hunger	Prolactin risk
Thesamorelin	Reducing visceral fat	No	Low
GHRP-6	Powerful GH release + Appetite	Yes	Moderate
Ipamorelin	Pure GH-stimulus without hunger	No	Low
CJC-1295	Prolonged GH secretion	No	Low

6. Withdrawal

Tesamorelin is the best choice for:
✔ Reducing visceral fat (especially in patients with metabolic disorders).
✔ Anti-aging therapy (without sudden GH spikes).
✔ Safe course (less side effects than GHRP-2/6).

Recommendations:

Start with 1 mg / day, control IGF-1.
Combine with diet and exercise for maximum fat burning.
It is contraindicated for tumors, pregnancy, and diabetes.