CJC-1295 or somatocrinin is a growth hormone synthesis stimulator. The peptideA peptide is a molecule consisting of a chain of amino acids linked together by peptide bonds. Peptides are shorter chains than proteins and usually contain from 2 to 50 amino acids. When the number of amino acids in a chain exceeds 50, such molecules are called proteins. Peptides can perform various functions in the body, including: Hormones, Neuropeptides, Antibiotics, Antioxidants is actively used by athletes, has positive reviews due to the absence of side effects and significant anabolic effect.
How the CJC-1295 peptide Works. It is one of the most popular and effective peptides for increasing your own levels of growth hormone (GH) and insulin-like growth factor-1 (IGF-1).
1. A brief overview of the mechanism
CJC-1295 is a growth hormone-releasing hormone (GHRH)analog. Its main task is to stimulate the pituitary gland for increased and more frequent production of its own human growth hormone. It is not an exogenous (external) growth hormone, but rather causes your body to produce its own more efficiently.
2. Detailed mechanism of action: step-by-step
Step 1: Binding to the receptor (Target)
CJC-1295 is a growth hormone releasing hormone (GHRH-R) receptor agonist.
These receptors are located in large numbers on the surface of somatotrophic cells in the anterior pituitary gland.
When the CJC-1295 molecule binds to GHRH-R, it activates it, mimicking the action of natural GHRH.
Activation of the receptor triggers a cascade of intracellular reactions (via G-proteins and secondary messengers, mainly cAMP).
This leads to an increase in the concentration of calcium ions (Ca2⁺) inside the cell.
This signal is a direct indication for the cell: ‘synthesize and release growth hormone.’
Step 3: Pulsing Secretion (Natural Pattern)
The key advantage of CJC-1295 over synthetic GH injections is that it preserves the natural pulsating nature of growth hormone secretion.
The pituitary gland secretes GH in impulses, the largest of which occurs at night during deep sleep. The CJC-1295 amplifies the amplitude and possibly frequency of these natural pulses, rather than creating a constant, non-changing GH background. This is considered more physiological and safe.
Step 4: Depot Effect (Extended Effect)
This is the most important technological feature of the CJC-1295. Regular GHRH has a half-life of only a few minutes.
A Drug AffinityAffinity is the ability of various cells and tissues to capture and bind certain chemical substances that have entered the body or are formed in it. Complex (DAC) is added to the CJC-1295 molecule , which allows the peptide to reversibly bind to albuminOne of the main proteins of the human body, responsible for maintaining normal blood composition and transporting various substances throughout the body. It also serves as a reserve source of amino acids. Albumins perform two very important functions: managing the distribution of water within the body, helping the blood transport vitamins, minerals, and medications. They are responsible for water exchange — they help retain it in the vessels and prevent it from excessively moving into the tissues (thus preventing the development of edema). Albumins influence the formation of tissue fluid, urine, and lymph, and also control the process of water absorption from the intestines. (the main blood protein).
As long as the peptide is bound to albumin, it is protected from rapid breakdown by enzymesEnzymes are proteins that accelerate chemical reactions in the body. They ensure the occurrence of metabolic processes such as food digestion, energy release, cell formation, and many others. and excretion by the kidneys.
It gradually ‘splits off’ from albumin, providing long-term stimulation of the pituitary gland. Due to this, the elimination half-life of CJC-1295 is about 6-8 days.
This allows you to make injections only 2-3 times a week to maintain a consistently high level of GH and IGF-1.
Step 5: Mediated Effects (End Result)
CJC-1295 itself does not produce direct effects. All results are mediated through an increase in the level of endogenous GH and, as a result, IGF-1:
Increased IGF-1 levels: Growth hormone stimulates the liver to produce insulin-like growth factor-1 (IGF-1). IGF-1 is largely responsible for the anabolic and restorative effects.
Starting processes:
Muscle growth: Increased protein synthesis and uptake of amino acidsAmino acids are the fundamental building blocks of proteins and play a key role in biological processes. There are a total of 22 standard amino acids used for protein synthesis in living organisms. by cells.
Lipolysis: Accelerated breakdown of adipose tissue (especially visceral and abdominal fat) for use as energy.
Improved recovery: Accelerated recovery of muscles, ligaments, joints and other tissues after training and injuries.
Bone strengthening: Increased bone mineral density.
Improving skin quality: Thickening of the skin, increased elasticity, collagenCollagen is a fibrillar protein, one of the main building elements of the body. It constitutes a significant part of connective tissues such as skin, tendons, joints, bones, and cartilage. Collagen provides strength, elasticity, and structural integrity to these tissues, giving them the ability to resist stretching. synthesis.
Strengthening the immune system.
Improve sleep and cognitive function.
3. Differences between CJC-1295 and CJC-1295 without DAC (Mod-GRF 1-29)
It is important not to confuse the two different connections:
Parameter
CJC-1295 (with DAC)
CJC-1295 without DAC (Mod GRF 1-29)
Half-Life
Long (6-8 days)
Short (about 30 minutes)
Injection Frequency
2-3 times per week
2-3 times per day, strictly timed to sleep, workouts, and fasting
Secretion Pattern
Maintains a constantly elevated baseline level of GH and IGF-1
Creates short and powerful peaks of GH, mimicking natural pulses
Application Strategy
For continuous high background support
For targeted pulse stimulation (before sleep, after workout)
They are often used together (the combination is known as ‘ Ipamorelin + Mod-GRF ‘ or ‘GHRP + GHRH’) for a synergistic effect: Mod-GRF (short GHRH) amplifies the pulse caused by GHRP (for example, Ipamorelin), and CJC-1295 with DAC provides background support.
4. Potential side effects
Because CJC-1295 increases its own GH level, side effects are similar to conditions with excess GH and are usually dose-dependent:
Water retention: One of the most common initial effects.
Tingling sensation in the extremities: Due to fluid retention and nerve damage.
Joint pain: Rarely, at high doses.
Increased blood sugar: GH is an insulin antagonist. Requires attention in individuals with insulin resistance.
Acromegaly-like symptoms: Changes in facial features, enlargement of internal organs are possible only with prolonged and significant excess of dosages. With adequate use, the risk is minimal.
Antibody formation: Theoretically, a synthetic analog can trigger an immune response, but in practice this is extremely rare due to the almost complete correspondence of the natural structure of GHRH.
Result
CJC-1295 works as a ‘prolonged signal’ for the pituitary gland, causing it to produce more of its own growth hormone in its natural, pulsating mode. Thanks to the albumin binding technology (DAC), it has a long-lasting effect, which makes it convenient to use and effective for maintaining consistently elevated levels of anabolic hormonesHormones are biologically active substances that are produced by specialized cells or glands (such as endocrine glands) and regulate various physiological processes in the body. They act as chemical signals that are transmitted through the bloodstream to organs and tissues to control and coordinate a wide range of functions, including metabolism, growth and development, reproduction, mood, and more. Examples include insulin, testosterone, estrogen, and adrenaline. (GH and IGF-1), leading to muscle growth, fat burning and overall rejuvenation of the body.
Properties and effects of CJC-1295
it has a pronounced anabolic effect, including:
speeding up the muscle growth process;
stimulation of strength and endurance indicators;
the effect of burning subcutaneous fat;
strengthens bones and joints, increasing their density, thereby preventing injuries;
complete rejuvenation of the body;
increases energy production;
increases the body’s protective functions.
CJC-1295 improves protein synthesis and thereby accelerates the growth of muscle fibers. Interesting fact! One injection of the peptide increases the concentration of growth hormone by three times. The course of application of CJC-1295 lasts 1-2 months, followed by a break of two weeks, if necessary, after the break, the course can be repeated. As for the dosage, it is 1-2 mg per kilogram of body weight of the athlete. The daily dosage is 100-200 mg, which is divided into three injections.
CJC-1295 can be combined with GHRP-6 and GHRP-2, in which case the effectiveness of the drug increases. The injections are usually given in the abdomen eight centimeters above the navel. All injections are performed using a hundred-division insulin syringe. The drug should be administered on an empty stomach at least two hours after a meal. The interval between injections is 4 hours or more.
The peptide should be stored in the refrigerator. In dry form, the shelf life is 18 months, if the bottle was hidden and diluted with saline solution, then when stored in the refrigerator, the period of use should not exceed two months. At the right dosage, the peptide does not cause side effects, which is why it has gained popularity among athletes.
