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Antistreptolysin-O

Antistreptolysin-O (ASLO) – role in the body

Anti-streptolysin-O (ASO) is an antibody produced by the immune system in response to streptolysin-O , a toxin released by Group A beta-hemolytic streptococcus (BSA).

The main role of the ADL:

  • Marker of a previous or current strep infection (sore throat, scarlet fever, erysipelas).
  • Helps to diagnose complications of streptococcal infection (rheumatic fever, glomerulonephritis).

Norm of ASLO in the blood

Reference values may vary from laboratory to laboratory, but usually:

  • Adults and children over 14 years of age: up to 200 IU / ml (international units per milliliter).
  • Children under 14 years of age: up to 150 IU / ml.

Elevated values indicate a recent streptococcal infection or autoimmune complications.

Symptoms of excess ASLO (high level)

By itself, an increase in ASLO does not cause symptoms, but indicates:

  1. Recent strep infection (sore throat, pharyngitis, scarlet fever) – possible:
  • Sore throat, fever, weakness.
  • Enlarged lymph nodes.
  1. Complications of streptococcal infection:
  • Rheumatic fever (damage to the heart, joints, skin).
    • Joint pain, shortness of breath, rash.
  • Post-streptococcal glomerulonephritis (kidney damage).
    • Edema, hypertension, blood in the urine.

ASLO deficit (low level)

A low ASLO level is a normthat means:

  • No recent strep infection.
  • Either the immune response was weak (rarely).

There are no symptoms of ASLO deficiency, since it is not a vital substance, but only a marker of infection.

Conclusions

  • ASLO is a marker of streptococcal infection and its complications.
  • The norm: up to 200 IU / ml in adults, up to 150 IU / ml in children.
  • High level: a sign of a recent infection or autoimmune complications (rheumatism, glomerulonephritis).
  • Low level: normal, does not require treatment.

If you have elevated ASLO, it is important to consult your doctor to rule out complications!