Organic acids in urine (OAT test)

Why is it needed?

The OAT test (Organic Acids Test) is a comprehensive analysis that evaluates metabolites (metabolic products) in the urine. These substances reflect the work of:
✔ Mitochondria (energy exchange).
✔ Intestinal microbiota.
✔ Detoxification systems.
✔ Neurotransmitter balance.

The test helps to identify:

• Mitochondrial dysfunction.
• Lack of vitamins (B12, B6, biotin).
• Fungal / bacterial infections (candida, Clostridium).
• Metabolic disorders (for example, lactate acidosis).

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What does the OAT test measure?

The analysis includes 70 + markersgrouped together:

1. Energy exchange (Krebs cycle):

• Lactate, pyruvate – signs of hypoxia or mitochondrial dysfunction.
• Citrate, alpha-ketoglutarate – indicators of the effectiveness of the Krebs cycle.

1. Microbial metabolites:

• D-lactate, hydroxymethylglutarate (candida, clostridium).
• Phenylpropionate, benzoate (excess of pathogenic bacteria).

1. Detoxification:

• Sulfates, glutathione-markers of liver load.

1. Neurotransmitters:

• Vanillylmandelate – VMA) is a metabolite of epinephrine/norepinephrine.
• Homovanilic acid (HVA) is a breakdown product of dopamineDopamine is a neurotransmitter and hormone that plays a key role in the brain's reward system, motivation, pleasure, learning, and movement regulation.Main functions: Stimulates feelings of pleasure and satisfaction. Involved in motivation and decision-making processes. Regulates motor activity. Affects memory, attention, and mood..

1. Oxidative stress:

• 8-OH-deoxyguanosine is a marker of DNA damage.

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Symptoms of abnormalities

If there is an excess of markers

• Lactate / pyruvate – chronic fatigue, muscle pain (mitochondrial dysfunction).
• D-lactate – – ‘fog in the head’, confusion (candidiasis, SIBR).
• Quinolinate – anxiety, depression (inflammation in the brain).
• Methylmalonic acid ↑ is a B12 deficiency.

If there is a shortage of markers

• Low alpha-ketoglutarate – lack of energy, anemia.
• Reduced sulfates – poor detoxification (allergies, chemical sensitivity).

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Standards in the OAT test

Specific references depend on the laboratory, but the approximate ranges are:

Note:

• The results are normalized to creatinine (to take into account the concentration of urine).
• References may differ for children and adults.

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What should I do if there are deviations?

1. Vitamin deficiency:

• With high methylmalonate – B12 (methylcobalamin).
• At high quinolinate – B6 (P-5-P).

1. Intestinal dysbiosis:

• Probiotics (Lactobacillus, Bifidobacterium).
• Antimicrobial agents (berberine, caprylic acid).

1. Mitochondrial support:

• CoQ10, L-carnitine, magnesium.

1. Detoxification:

• Glutathione, N-acetylcysteine (NAC).

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When is the OAT test scheduled?

• Chronic fatigue, fibromyalgia.
• Neurological disorders (autism, ADHD).
• Food intolerances and allergies.
• Suspected candidiasis or SIBR.

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How do I take the test?

• Morning urine (the first portion after sleep).
• Exclude within 48 hours :
• Alcohol, caffeine.
• Vitamin supplements (especially B2, B12).

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Conclusion

The OAT test is a window into your metabolism that shows an imbalance of energy, microbiota, and detoxification.
Нормы Norms are individual, but key markers are:

• Lactate <2.0 mg / g,
• Methylmalonic acid <3.0 mmol / g
  . Коррек Correction depends on the detected disorders (vitamins, probiotics, antioxidants).