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Coenzyme Q10 (CoQ10)

Coenzyme Q10 (Ubiquinone) – it is a vitamin-like substance that plays a key role in the production of energy (ATP) in the mitochondria and the protection of cells from oxidative stress.

Main functions:

  1. Energy metabolism -participates in the respiratory chain of mitochondria, helping to synthesize ATP (especially important for the heart, brain, and muscles).
  2. Antioxidant protection -neutralizes free radicals, prevents cell damage.
  3. Heart support -improves myocardial contractility, reduces the risk of atherosclerosis.
  4. Slowing down aging – CoQ10 levels decrease with age.
  5. Immune system -increases the activity of phagocytes.

Symptoms of CoQ10 deficiency

A deficit occurs when:

  • Over the age of 40 (natural decrease in synthesis).
  • Taking statins (cholesterol-lowering drugs block CoQ10 synthesis).
  • Chronic diseases (heart failure, diabetes, Parkinson’s disease).

Signs of a shortage:
✔ Chronic fatigue, weakness.
✔ Muscle achesand cramps (especially when taking statins).
Shortnessof breath, arrhythmia (due to decreased energy in the heart muscle).
✔ Memory loss, cognitive impairment.
✔ High blood pressure.

Symptoms of excess CoQ10

Overdose is extremely rare, as CoQ10 is non-toxic. Possible effects when taking large doses (>300 mg / day):

  • Nausea, diarrhea.
  • Headache, insomnia.
  • Decreased appetite.

Note: A natural excess is not possible – the excess is excreted in the bile.

CoQ10 standards in analyses

CoQ10 levels are measured in blood plasma or lymphocytes (a more accurate method).

ParameterStandardOptimal level
Blood plasma0.5-1.5 mcg / ml>1.0 mcg / ml
Lymphocytes30-150 nmol / mg of protein>50 nmol / mg

When is the test scheduled?

  • With muscle weakness while taking statins.
  • For heart failure, migraines.
  • To assess the antioxidant status.

How to increase CoQ10?

  1. Food:
  • Fatty fish (herring, sardines).
  • Beef, chicken heart.
  • Nuts, seeds, spinach.
  1. Supplements (as directed by your doctor):
  • Ubiquinone (the usual form) – 100-200 mg / day.
  • Ubiquinol (reduced form– – better absorbed, especially after 40 years.
  1. Reducing risk factors:
  • Quitting smoking (accelerates oxidative stress).
  • Blood sugar control (diabetes lowers CoQ10).

Conclusion

CoQ10 is a vital component for energy and antioxidant protection.
Deficiency is manifested by fatigue, muscle weakness, and heart problems.
, Blood norm: 0.5-1.5 mcg / ml (plasma), > 50 nmol / mg (lymphocytes).
Supplements are effective for proven deficiencies or statin use.

Example: If the CoQ10 level is < 0.5 mcg / ml, it is recommended to take 100-200 mg/day in the form of ubiquinol.